Does Cannabis Interact with Minoxidil?

In this question, the pharmacist discusses if cannabis oil interacts with minoxidil, taken orally.
Does Cannabis Interact with Minoxidil?

Kay S. Asked

Does Cannabis oil interact with minoxidil (oral dose)?


Minoxidil is a prescription medication originally developed to treat high blood pressure, but is now mainly used to treat hair loss.
Cannabis and minoxidil both cause changes in blood pressure, but more research is needed to better understand this interaction.


Hi Kay, thank you for your question.

What is Minoxidil?

Originally designed as a drug to treat high blood pressure, minoxidil is now primarily used to treat hair loss. Interestingly, during its development, the unanticipated side effect of hair growth became evident, ultimately driving its evolution into treatment for hair loss. So, minoxidil has dual uses - one for hair loss and another for managing high blood pressure, although its use for high blood pressure is less common today due to the availability of other more effective medications, with fewer side effects. 

How does Minoxidil work?

The precise mechanism of action of minoxidil is unknown. However, a few different pathways may play a role. 

Vasodilation: Minoxidil is classified as a vasodilator, meaning it relaxes and widens blood vessels. This relaxation can lead to increased blood flow to the hair follicles, potentially enhancing their function and promoting hair growth.

Prolonged Anagen Phase: Minoxidil has the potential to extend the anagen, or growth, phase of hair follicles. This extension can result in thicker hair and increased overall hair density.

Potassium Channel Opening: Minoxidil is thought to open potassium channels within cells. This action may contribute to increased hair growth and thicker hair.

Does cannabis oil interact with Minoxidil?

Unfortunately, we couldn't find any studies about this specific interaction. There is likely not enough scientific research to definitively determine if cannabis oil interacts with minoxidil.

However, both drugs can affect blood pressure, and combining them might lead to adverse effects. Remember, Minoxidil can lower blood pressure and that's why it was originally developed. Cannabis usually increases blood pressure shortly after use, but can also decrease blood pressure.

For that reason, it’s essential to consult with a healthcare professional who can provide personalized advice based on your specific circumstances and medical history before combining these two drugs. 

  1. Loniten. New York, NY: Pfizer; 2015. [package insert].

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