Published: Jul 17, 2021

Can I use CBD oil while taking Spironolactone?

In our latest question and answer, the medical cannabis pharmacist discusses if it is ok to use CBD oil while taking spironolactone.

Answered by: Dr. Geoffrey Brown, PharmD

CBD Oil

Jim Asked

I take spironolactone for high blood pressure and want to start using CBD oil for anxiety. Is it safe to use CBD oil while taking spironolactone?

Summary

W

There are no known major drug interactions between CBD and spironolactone.

W

Always be sure to purchase hemp-derived CBD from a reputable source; one that lab tests their products and manufactures them in a CGMP facility.

W

Be sure to let your doctor that manages your spironolactone therapy know that you're using CBD.

Answer

Hi Jim and thanks for your question. In short, there doesn’t seem to be any major drug interactions I would be concerned about with this combination.

Spironolactone is a potassium sparing diuretic that’s used in combination with other medications to manage high blood pressure. Usually your doctor will try other medications before using spironolactone and if they’re ineffective they’ll add it on to try and help. Spironolactone works by binding to ion channels in the kidneys and increasing the excretion of sodium and water, while retaining potassium (hence it’s in a drug class called “potassium sparing diuretics”).

CBD is one of the primary cannabinoids found in cannabis and is omnipresent in consumer products nowadays. CBD’s widespread availability is largely attributed to the 2018 Farm Bill which legalized hemp nationwide. Hemp-derived CBD products are very commonly used for occasional anxiety or stress.

CBD is metabolized by enzymes in the liver, therefore taking CBD can alter the way your liver metabolizes other drugs. But Spironolactone isn’t metabolized by the enzymes that CBD impacts, so there’s no interference with metabolism. While there’s no apparent interaction between CBD and spironolactone you should always check with your doctor or pharmacist before starting any new prescription, over-the-counter drug, herbal supplement, or natural product to make sure it’s safe to take with CBD and any other medications you might be taking.

CBD on its own is relatively safe and well tolerated, but it can alter the metabolism of other drugs. This could result in changes in a drug’s concentration in your blood. If levels increase too high, certain medications could produce adverse effects and toxicity. If the levels go to low, the drug could become ineffective.

One more thing is to always purchase CBD from a reputable source. A couple of quality standards you can check for are if the manufacturer holds a Current Good Manufacturing Practices certification and if the products are lab tested for contaminants.

Thanks again, and feel free to reach out with any further questions!

References

Epidiolex [package insert]. Carlsbad, CA: Greenwich Biosciences, Inc. 2020. 

Aldactone [package insert]. New York, NY: Pfizer, Inc. 2008. 

Was this post helpful?

Dr. Geoffrey Brown, PharmD

Dr. Geoffrey Brown is a registered medical cannabis pharmacist in New York State and the founder of CannaBuff. He graduated from the University at Buffalo with a Doctor of Pharmacy degree in 2018. His cannabis research has been featured by the national advocacy group NORML and local news organizations. Please feel free to reach out to him if you want to connect!

Related Questions

Does HIPAA Apply to Medical Cannabis Dispensaries?

In our latest question and answer, the pharmacist discusses if your purchase history at dispensaries is protected by HIPAA.

Medical marijuana New York Statee

Medical Marijuana in NY: The Definitive Guide

In our latest question and answer, the pharmacist discusses common questions about NY’s medical marijuana program.

Can I receive a Medical Cannabis Card if I Have My Pistol Permit

In our latest question and answer, our expert discusses if having a pistol permit prevents you from obtaining a medical cannabis card.

blackout

Can Marijuana Make you Blackout?

In our latest question and answer, our cannabis expert discusses what exactly a blackout is and whether or not marijuana can make you blackout.

CBD oil

Does CBD reduce the effects of THC?

In our latest question and answer, our pharmacist discusses whether or not CBD reduces the effects of THC.

CBD Oil

Is it Safe to Use CBD and Zoloft (sertraline) at the same time?

In our latest question and answer, the medical cannabis pharmacist discusses if it is ok to use CBD oil while taking sertraline.

CBD Oil

When should you avoid using CBD?

In our latest question and answer, the medical cannabis pharmacist discusses when you should take caution or avoid using CBD.

CBD oil

Does CBD reduce the effects of THC?

In our latest question and answer, our pharmacist discusses whether or not CBD reduces the effects of THC.